Microsatellite instability in myeloid leukemias [letter; comment]
نویسندگان
چکیده
منابع مشابه
CORRESPONDENCE Microsatellite Instability in Myeloid Leukemias
Somatic instability of variable number of tandem repeat (VNTR or microsatellite) sequences has been described recently in colorectal cancer as an indicator of a novel mechanism of carcinogenesis.' The recent report in Blood by Wada et aI2 suggested that microsatellite instability is a frequent feature in the evolution of chronic myeloid leukemia (CML) from chronic phase to blast crisis, and the...
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Microsatellites are short tandem repeat sequences dispersed throughout the genome. Their instability at multiple genetic loci may result from mismatch repair errors and it occurs in hereditary nonpolyposis colorectal cancer. This instability is also found in many sporadic cancers. In order to evaluate the importance of this process in myeloid leukemias, we studied five loci in different chromos...
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ژورنال
عنوان ژورنال: Blood
سال: 1994
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v84.9.3236.3236